Long-term Antipsychotic Treatment and Brain Volumes… More medication means less white & gray matter

It’s official: Antipsychotics shrink the brain!

Ho, Andreasen and colleagues report that:

More antipsychotic treatment was associated with smaller gray matter volumes. Progressive decrement in white matter volume was most evident among patients who received more antipsychotic treatment. Illness severity had relatively modest correlations with tissue volume reduction, and alcohol/illicit drug misuse had no significant associations when effects of the other variables were adjusted

JAMA Network | JAMA Psychiatry | Long-term Antipsychotic Treatment and Brain Volumes:  A Longitudinal Study of First-Episode Schizophrenia.

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