JAMA Psychiatry | Long-term Antipsychotic Treatment and Brain Volumes

“Conclusions  Viewed together with data from animal studies, our study suggests that antipsychotics have a subtle but measurable influence on brain tissue loss over time, suggesting the importance of careful risk-benefit review of dosage and duration of treatment as well as their off-label use.”

JAMA Network | JAMA Psychiatry | Long-term Antipsychotic Treatment and Brain Volumes:  A Longitudinal Study of First-Episode Schizophrenia.

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