Category Archives: neuroleptics

Study finds some schizophrenics do well without long-term antipsychotics – Chicago Tribune

“Patients who go off antipsychotics may drop off the radar of medical professionals, who mostly focus on the sickest patients, researchers say. And, in an era of intense stigma, patients who are off antipsychotics and functioning well are unlikely to discuss their experiences openly.”

” by the fifth year of the study, the schizophrenia patients who were off antipsychotics for extended periods actually were doing better than the patients who were on antipsychotics — perhaps because they had been less ill to begin with.”

Why do psychiatric drugs have withdrawal syndromes?

 – Beyond Meds

Generally, prolonged withdrawal syndrome is not recognized by medicine. You will find very few doctors to diagnose it and still fewer to treat it. This is a collection of links that might help you educate yourself so that you can find more appropriate care when the time comes as well as hopefully avoiding falling ill at all.

Why do psychiatric drugs have withdrawal syndromes?

 – Beyond Meds.

psych drugs

Johnson & Johnson to Pay More Than $2.2 Billion to Resolve Criminal and Civil Investigations | OPA | Department of Justice

“to resolve criminal and civil liability” for “promotion for uses not approved as safe and effective… and payment of kickbacks to physicians and to the nation’s largest long-term care pharmacy provider.” This is the “largest health care fraud settlements in U.S. history, including criminal fines and forfeiture totaling $485 million and civil settlements with the federal government and states totaling $1.72 billion.”

Johnson & Johnson to Pay More Than $2.2 Billion to Resolve Criminal and Civil Investigations | OPA | Department of Justice.

Neuropsychopharmacology – The Influence of Chronic Exposure to Antipsychotic Medications on Brain Size before and after Tissue Fixation: A Comparison of Haloperidol and Olanzapine in Macaque Monkeys

Three groups of six macaque monkeys each were exposed to oral haloperidol, olanzapine or sham for a 17–27 month period…. we observed an 8–11% reduction in mean fresh brain… both drug-treated groups compared to sham animals. The differences were observed across all major brain regions

Neuropsychopharmacology – The Influence of Chronic Exposure to Antipsychotic Medications on Brain Size before and after Tissue Fixation: A Comparison of Haloperidol and Olanzapine in Macaque Monkeys.

JAMA Psychiatry | Long-term Antipsychotic Treatment and Brain Volumes

“Conclusions  Viewed together with data from animal studies, our study suggests that antipsychotics have a subtle but measurable influence on brain tissue loss over time, suggesting the importance of careful risk-benefit review of dosage and duration of treatment as well as their off-label use.”

JAMA Network | JAMA Psychiatry | Long-term Antipsychotic Treatment and Brain Volumes:  A Longitudinal Study of First-Episode Schizophrenia.

Long-term Antipsychotic Treatment and Brain Volumes… More medication means less white & gray matter

It’s official: Antipsychotics shrink the brain!

Ho, Andreasen and colleagues report that:

More antipsychotic treatment was associated with smaller gray matter volumes. Progressive decrement in white matter volume was most evident among patients who received more antipsychotic treatment. Illness severity had relatively modest correlations with tissue volume reduction, and alcohol/illicit drug misuse had no significant associations when effects of the other variables were adjusted

JAMA Network | JAMA Psychiatry | Long-term Antipsychotic Treatment and Brain Volumes:  A Longitudinal Study of First-Episode Schizophrenia.